Natto Extract

What is natto?

Natto stems from China and is like the fermented bean and strange taste bean of China. It was recorded in ancient books that natto began to be prepared since the Qin Dynasty and Han Dynasty of China. Natto started from the lobster sauce of China.

Relevant story

According to Food Culture·New Market, both nattos are concerned with China. Especially, salty natto was introduced to Japan in the Nara period. In Japan, natto is also called "Chi", which has an edible history of more than 2000 years in Japan. It is the same with the lobster sauce taken by Chinese at present.

Since natto was introduced to Japan, it has been developed according to the natural conditions and social customs of Japan. For example, soy sauce paste is used in place of lobster sauce, or sauce is used in place of lobster sauce juice.
Since it was introduced by monks from China to Japanese temples, natto was first developed in temples. For example, Dalong temple natto, Dade temple natto, ikyu natto, binming natto of daifukuji temple, baqiao natto of Gosinji temple have been well-known special local products of these temples. Since lobster sauce is prepared in the kitchens of temples (called "Na Suo" in Chinese) and placed into jars or barrels for storage, Japanese call them "Tang natto" or "salty natto". Japanese regards it as nutritional food and flavoring, while Chinese uses it as flavoring after frying or steaming it.
In recent years, it has been shown by the studies by Japanese medical scientists and physiologists that the proteins of soybean are insoluble, while after soybean is prepared into natto, proteins become soluble and part of the proteins are decomposed into amino acids. In addition, natto bacteria and related bacteria can produce different kinds of enzymes, which are helpful for the digestion and absorption in stomach and intestine. The components of natto are as follows: water 61.8%, crude protein 19.26%, crude fat 8.17%, carbohydrate 6.09%, crude fiber 2.2%, ash content 1.86%. As a vegetable food, it has abundant crude protein and fat. Natto is a high protein nourishing food. The enzymes contained in natto can eliminate the cholesterol in vivo, decompose the acidified lipids, and recover the abnormal blood pressure to normal.

In recent years, people pay increased attention to the nutritional ingredients and medical treatment functions of natto, and a "natto hot wave" has formed in Japan. Even there is a slogan called "natto saves earth". In the United States and European countries, natto is called the "super nutritional food of the 21st century".

The population more than 60 years old in China will increase to 300 million in 2004, and old people are the main group affected by cardiovascular and cerebrovascular diseases. Due to the change in diet structure, increased intake of cholesterol, working and living pressure, reduced exercises and environment pollution, the average age of the patients of cardiovascular and cerebrovascular diseases decreases, and the proportion of patients in thirties and fourties suffering from cardiovascular and cerebrovascular diseases is on the increase. However, there are few health food with thrombolysis functions in the market. Natto fills up the blank in the domestic market and has more effective thrombolysis actions than drugs, and its fibrinolysis activity is as high as 35000FU/g.

Main ingredients of the product:

Natto kinase, phospholipid powder, Vitamin C, grape pip extract, odorless garlic extract powder, soybean meal.

Natto is a special food with mucus on the surface prepared by fermenting boiled soybean with natto bacteria. The main nutritional ingredients of natto include natto kinase, natto bacteria, high quality small molecule proteins (peptides), dipicolinic acid, saponin, lecithin, superoxide dismutase, Vitamin K2, biological polysaccharide, isoflavone etc.
The main effects of natto include thrombolysis, antibacterial action, reducing osteoporosis, antitumous effect, regulating intestine function and increasing protein digestibility.

On one day in 1980, Professor Hiroyuki Sumi (Japan) placed a common thrombolytic drug on a given amount of thrombi, and the thrombolysis took a whole night; when natto was used in place of the thrombolytic drug, thrombolysis took only 3 hours. In 1987, Professor Hiroyuki Sumi extracted natto kinase, a substance with supernatural thrombolytic actions and extensive health care functions, from natto.

The thrombolytic actions of natto kinase include direct thrombolytic actions and indirect thrombolytic actions. The mechanism of actions is shown in the following figure "Schematic Illustration for the In Vivo Thrombolytic Actions of Natto Kinase".

* Direct thrombolytic actions
* Actions of plasminogen activator
* Actions of pro-urokinase activator

Advantages of natto kinase: good thrombolytic effects and easy absorption after oral administration, no antigenicity, no toxic and side effects, safe and reliable for long-term administration, low price.

Phospholipid powder

Phospholipid powder is lecithin powder, which is a principal component of the cell membrane of the human body. There is lecithin in the cells of different kinds of organs and tissues in our body, such as nervous system. The content of lecithin is especially abundant in some important organs and tissues, such as liver. There is 200mg of lecithin in 100 ml blood. In total, the content of lecithin in the human body is one percentage of live weight. At present, it has been widely accepted in the world lecithin has 4 main functions: 1. cell activation; 2. dissolving cholesterol; 3. improving brain-power and preventing senile dementia; potentializing the functions of Vitamin E.

Vitamin C

* Vitamin C is an important component for the formation of collagen. Vitamin C forms collagen with proteins and calcium, and collagen is an important substance for tissues, cells, muscles, blood vessels, teeth, skeletons and the growth and reparation in human body.
* It can reduce harmful cholesterol and lower blood pressure, prevent arteriosclerosis and decrease the formation of thrombi in veins.
* It can improve the functions of cardiac muscle, reduce capillary fragility and increase the resistibility of body.
* It can resist free radicals and contribute to cancer and scurvy prevention.
* It also can facilitate wound healing and increase the sensibility to wounds and infections.

4) Grape pip extract
Grape pip extract is taken from red grapestones and the main component is pro-cyanidin. Grape pip extract can prevent and treat more than 70 types of diseases and this function mainly depends on its capacity of eliminating free radicals.

The main effects of grape pip extract on circulating system include:

* Improving angiopathy, repairing inner wall of arteries and reducing varicosity and phlebitis
* Decreasing the blood volume in lower extremities
* Enhancing blood vessels and decreasing subcutaneous hemorrhage
* Promoting blood circulation;
* Reducing the risk of apoplexy
* Lowering cholesterol and blood fat

5) Garlic extract
Garlic (allium sativum) is the bulbs if garlic, a per nnial herb of lily family, which contains abundant protein, fat, saccharides, amino acids, mineral substances and vitamins. 100g garlic contains 0.24g of Vitamin B. Garlic has significant healthy actions and medicinal values. It has been shown by medical research that garlic contains a great variety of biologically active substances with the functions of anti-inflammation, elimination of toxicant, reducing cholesterol and preventing and curing cerebral thrombosis and coronary heart disease.

6) Soybean meal
It is used as the auxiliary materials for filling capsules, which is safe and nutritional and different from other synthetic auxiliary materials.

It has been proved by a great deal of literature and experiments in the conditions simulating the conditions in stomach, 75% of the fibrinolytic activity of natto kinase is lost, and even when the pH value recovers to neutral, the fibrinolytic activity cannot be recovered, either. This indicates pepsin has inconvertible inactivating effects on natto kinase. Therefore, in order to avoid the first pass effect of stomach environment, enteric-coated capsule should be used if it is taken via oral administration. The existing natto products in the market are capsules dissolved in stomach and most of the fibrinolytic activity is lost after administration. TIENS Natto Extract Capsules are produced using advanced enteric capsule coating and sealing techniques in order to ensure the intestinal tract absorption of intact protein molecules and the thrombolytic actions of them.

Relevant story: Dr. Hiroyuki Sumi, who is honored "Father of natto" said in a lecture in SupplySide West show: "Natto kinase contains no Vitamin K because Vitamin K may affect the actions of anticoagulant drugs." There is seldom Vitamin K deficiency and no additional supplement is required for common people except when antibiotics are used for a long time. Therefore, when Vitamin K is eliminated, more people can take it without worrying about drug interactions. TIENS Natto Extract Capsules contains no Vitamin K, so there is no need to worry about its drug interactions with anticoagulants.
This product is produced via fungi fermentation and used as nutrition supplement with authorization of the United States, so the safety of this product is assured.

Efficacy of the product:

* Preventing cardiovascular diseases
* Assistant treatment for thrombosis
* Help to ameliorate blood circulation

TIENS Natto Extract Capsules has more effective thrombolytic effects than drugs and the activity of fibrinolysis is as high as 35000FU/g, so that it can effectively prevent cardiovascular and cerebrovascular diseases, such as myocardial infarction, cerebral embolism, senile dementia etc. This product is produced via fungi fermentation and used as nutrition supplement with authorization of the United States, so the safety of this product is assured.

Target customers:

Middle-aged and senile patients with cardiovascular diseases.

Edible method:

2 capsules each day, one capsule in the morning and one capsule in the evening.